BENZOIC ACID, 4-AMINO-3-BROMO-, METHYL ESTER - Names and Identifiers
BENZOIC ACID, 4-AMINO-3-BROMO-, METHYL ESTER - Physico-chemical Properties
Molecular Formula | C8H8BrNO2
|
Molar Mass | 230.06 |
Density | 1.6270 (rough estimate) |
Melting Point | 105-109 °C |
Boling Point | 334.2±22.0 °C(Predicted) |
Flash Point | 155.9°C |
Vapor Presure | 0.00013mmHg at 25°C |
Appearance | White to Brown to Red Powder or Crystalline |
Color | Brown |
pKa | 0.41±0.10(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
Refractive Index | 1.6120 (estimate) |
MDL | MFCD01861385 |
BENZOIC ACID, 4-AMINO-3-BROMO-, METHYL ESTER - Risk and Safety
Risk Codes | R22 - Harmful if swallowed
R36 - Irritating to the eyes
R36/37/38 - Irritating to eyes, respiratory system and skin.
|
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37 - Wear suitable protective clothing and gloves.
S37/39 - Wear suitable gloves and eye/face protection
|
UN IDs | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
HS Code | 29163100 |
Hazard Note | Irritant |
BENZOIC ACID, 4-AMINO-3-BROMO-, METHYL ESTER - Introduction
Methyl 4-amino-3-bromobenzoate is an organic compound with the chemical formula C8H8BrNO2. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: Methyl 4-amino-3-bromobenzoate is a colorless to pale yellow solid.
-Melting point: about 45-50 ℃.
-Boiling point: about 238-240 ℃.
-Density: 1.48-1.50g/cm³.
-Solubility: Slightly soluble in water, soluble in organic solvents such as ethanol and dichloromethane.
Use:
-4-Amino-3-bromobenzoic acid methyl ester is an important pharmaceutical intermediate, commonly used in the synthesis of antibiotics and other drugs.
-It is also used in nucleophilic substitution reactions and aromatic substitution reactions in the field of organic synthesis.
Preparation Method:
- 4-amino -3-bromobenzoic acid methyl ester can be prepared by nucleophilic substitution reaction of bromotoluene. First, bromotoluene reacts with methyl carbamate to produce methyl 4-amino-3-bromobenzoate under the catalysis of alkali.
Safety Information:
- 4-amino -3-bromobenzoic acid methyl ester has a certain toxicity, irritation to the eyes, skin and respiratory system. During use, appropriate protective equipment should be worn to avoid direct contact.
-should be away from the fire and high temperature environment, to avoid the production of flammable vapor.
-During storage, it should be kept in a cool, dry, well-ventilated place, and avoid contact with oxidants and strong acids.
Last Update:2024-04-09 02:00:41